Anti-DOK4 Polyclonal Antibody

K001609P-50ul	Solarbio	50ul	960.00元
K001609P-100ul	Solarbio	100ul	1600.00元

英文名称	Rabbit DOK4 Polyclonal Antibody
应用2	WB IF
克隆类型2	Polyclonal Antibody
别名	IRS-5;IRS5
应用	WB,IF
稀释比例	WB1:500-1:2000 IF1:50-1:200
交叉反应	Human Mouse Rat
蛋白分子量	37kDa
Gene ID	55715
保存	Store at -20°C. Avoid freeze / thaw cycles.Stable for one year from the date of shipment.
储存液	PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
亚型	IgG
免疫原	Recombinant Protein of human DOK4
性状	Lyophilized or Liquid
Swiss Prot	Q8TEW6
来源	Rabbit
背景资料	The downstream of kinase family (Dok-1-7) are members of a class of docking proteins that interact with receptor tyrosine kinases and, via this interaction, mediate biological responses within the body. Dok-4 (Downstream of kinase-4) is a 326 amino acid protein that contains one PH domain and one IRS-type PTB domain and belongs to the Dok family of interacting proteins. Expressed in a variety of tissues with highest expression in liver, heart, kidney and skeletal muscle, Dok-4 plays an important role in Ret-mediated neurite outgrowth and may link Ret with downstream effectors during neuronal differentiation. Additionally, Dok-4 is thought to play a positive role in the activation of MAPK pathways and may participate in T-cell induced immune system regulation. Overexpression of Dok-4 is associated with clear cell renal cell carcinoma, suggesting a role for Dok-4 in tumorigenesis.