IGF2R-SPECIFIC 抗体
Applications
| In-house applications |
ELISA, WB, IHC, IF, IP, FC Application not tested? Please see our Guarantee. |
| Species specificity |
Human; other species not tested. |
|
Images
Prev12Next
 HepG2 cells were subjected to SDS PAGE followed by western blot with 20253-1-AP(IGF2R-Specific antibody) at dilution of 1:500 Immunohistochemistry of paraffin-embedded human liver cancer slide using 20253-1-AP( IGF2R-Specific Antibody) at dilution of 1:50 Immunohistochemistry of paraffin-embedded human liver cancer slide using 20253-1-AP( IGF2R-Specific Antibody) at dilution of 1:50 IP Result of anti-IGF2R-Specific (IP:20253-1-AP, 4ug; Detection:20253-1-AP 1:500) with HepG2 cells lysate 3480ug. Immunofluorescent analysis of HepG2 cells using 20253-1-AP( IGF2R-Specific Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) 1X10^6 HepG2 cells were stained with .2ug IGF2R-Specific antibody (20253-1-AP, red) and control antibody (blue). Fixed with 4% PFA blocked with 3% BSA (30 min). Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) with dilution 1:1500.
|
| Positive WB detected in |
HepG2 cells, A431 cells, L02 cells |
| Positive IP detected in |
HepG2 cells |
| Positive IHC detected in |
Human liver cancer tissue, human liver tissue |
| Positive IF detected in |
HepG2 cells |
| Positive FC detected in |
HepG2 cells |
| Recommended dilution |
WB : 1:1000-1:10000
IP : 1:200-1:2000
IHC : 1:20-1:200
IF : 1:20-1:200 |
IGF2R-SPECIFIC 抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
| Source |
Rabbit |
Purification method |
Antigen affinity purification |
| Isotype |
IgG |
Storage |
PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC. |
Immunogen Information
| Immunogen |
Peptide |
Full name |
Insulin-like growth factor 2 receptor |
Calculated molecular
weight |
274 kDa |
Observed molecular
weight |
274 kDa |
GenBank accession
number |
NM_000876 |
Gene ID (NCBI) |
3482 |
| Gene symbol |
IGF2R |
Synonyms |
CD222, CI Man 6 P receptor, CI MPR, CIMPR, IGF II receptor, IGF2R, M6P R, M6P/IGF2 receptor, M6P/IGF2R, M6PR, MPR 300, MPR1, MPRI |
Background IGF2R-SPECIFIC 抗体
|
IGF2R, also named as MPRI, CI Man-6-P receptor, CI-MPR, M6PR, IGF-II receptor, M6P/IGF2R, MPR 300 and CD222, belongs to the MRL1/IGF2R family. IGF2R transports of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. IGF2R is a lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. IGF2R acts as a positive regulator of T-cell coactivation, by binding DPP4. The antibody is specific to IGF2R. IGF2R-SPECIFIC 抗体
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