c-MYC 抗体-抗体-抗体-生物在线
上海信裕生物科技有限公司
c-MYC 抗体

c-MYC 抗体

商家询价

产品名称: c-MYC 抗体

英文名称: c-MYC Antibody

产品编号: XY 10828-1

产品价格: null

产品产地: 中国/美国

品牌商标: XYbscience

更新时间: 2023-08-17T09:55:27

使用范围: WB,ELISA,IHC-P,IHC-F,IF

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 C-MYC 抗体

Applications
In-house applications ELISA, WB, IP, IHC     Application not tested? Please see our Guarantee.
Published applications IF, WB Publications 7 citations –view here
Species specificity Human, Mouse; other species not tested.
Published Species Human
Images
Prev1NextView more validation data
  • 10828-1-AP;Raji cellsRaji cells were subjected to SDS PAGE followed by western blot with 10828-1-AP(MYC antibody) at dilution of 1:1000
  • 10828-1-AP;human lymphoma tissueImmunohistochemical of paraffin-embedded human lymphoma using 10828-1-AP(MYC antibody) at dilution of 1:50 (under 40x lens)
  • 10828-1-AP;HL-60 cellsIP Result of anti-MYC (IP:10828-1-AP, 3ug; Detection:10828-1-AP 1:500) with HL-60 cells lysate 1200ug.
Positive WB detected in Raji cells, HL-60 cells, mouse embryo tissue
Positive IP detected in HL-60 cells
Positive IHC detected in Human lymphoma tissue, human breast cancer tissue, human prostate cancer tissue
Recommended dilution WB : 1:500-1:5000
IP : 1:200-1:2000
IHC : 1:20-1:200
C-MYC 抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
Source Rabbit Purification method Antigen affinity purification
Isotype IgG Storage PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen Information
Immunogen C-MYC fusion protein ag1263 Full name V-myc myelocytomatosis viral oncogene homolog (avian)
Calculated molecular
weight
49 kDa Observed molecular 
weight
62-65 kDa, 50 kDa
GenBank accession 
number
BC000141 Gene ID (NCBI) 4609
Gene symbol MYC Synonyms BHLHe39, c Myc, c-Myc, MRTL, MYC, Myc proto oncogene protein, Proto oncogene c Myc, Transcription factor p64
BackgroundC-MYC 抗体

MYC contains one basic helix-loop-helix (bHLH) domain. This protein is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. It seems to activate the transcription of growth-related genes. It binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. This antibody is a rabbit polyclonal antibody raised against recombinant protein of human MYC.The 50kDa band recognized by antibody is the native form of MYC, while the other bands, between 60-70kDa, are the phosphorylated form of MYC [PMID: 12189186]C-MYC 抗体

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