IRS1抗体-抗体-抗体-生物在线
上海信裕生物科技有限公司
IRS1抗体

IRS1抗体

商家询价

产品名称： IRS1抗体

英文名称： IRS1Antibody

产品编号： XY17509-1

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

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 IRS1抗体

Applications
In-house applications ELISA, WB, IHC, IP, IF     Application not tested? Please see our Guarantee.
Published applications WB Publications 1 citations –view here
Species specificity Human; other species not tested.
Published Species Mouse
Images
Prev12NextView more validation data
  • 17509-1-AP;A549 cellsA549 cells were subjected to SDS PAGE followed by western blot with 17509-1-AP(IRS1 antibody) at dilution of 1:400
  • 17509-1-AP;A549 cellsIP Result of anti-IRS1 (IP:17509-1-AP, 5ug; Detection:17509-1-AP 1:1000) with A549 cells lysate 3500ug.
  • 17509-1-AP;human breast cancerImmunohistochemical of paraffin-embedded human breast cancer using 17509-1-AP(IRS1 antibody) at dilution of 1:100 (under 40x lens)
  • 17509-1-AP;human breast cancerImmunohistochemical of paraffin-embedded human breast cancer using 17509-1-AP(IRS1 antibody) at dilution of 1:100 (under 10x lens)
  • 17509-1-AP;A549 cellsImmunofluorescent analysis of A549 cells using 17509-1-AP( IRS1 Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Positive WB detected in A549 cells, A431 cells, HEK-293 cells, PC-3 cells
Positive IP detected in A549 cells
Positive IHC detected in Human breast cancer tissue, human liver tissue
Positive IF detected in A549 cells
Recommended dilution WB : 1:500-1:5000
IP : 1:500-1:5000
IHC : 1:20-1:200
IF : 1:20-1:200
IRS1抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
Source Rabbit Purification method Antigen affinity purification
Isotype IgG Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen Information
Immunogen IRS1 fusion protein ag11714 Full name Insulin receptor substrate 1
Calculated molecular
weight		 1242aa,132 kDa Observed molecular 
weight		 160-185 kDa
GenBank accession 
number		 BC053895 Gene ID (NCBI) 3667
Gene symbol IRS1 Synonyms HIRS 1, insulin receptor substrate 1, IRS 1, IRS1
BackgroundIRS1抗体

Insulin receptor substrate 1 (IRS1) was the first cloned and characterized member of the IRS family which are involved in insulin receptor (IR) and insulin-like growth factor I receptor (IGF-IR) signaling. IRS1 is phosphorylated by insulin receptor tyrosine kinase and is involved in various cellular processes including DNA repair fidelity, transcriptional activity, and cell growth can support tumor development and progression. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance. IRS1 has a predicted molecular weight of 132 kDa, however, as a result of its extensive serine phosphorylation it separates on a SDS gel as a band of approximately 160-185 kDa.IRS1抗体

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