AKT1/AKT2/AKT3 (phospho Y315/Y316/Y312) polyclonal antibody
产品名称： AKT1/AKT2/AKT3 (phospho Y315/Y316/Y312) polyclonal antibody
英文名称： AKT1/AKT2/AKT3 (phospho Y315/Y316/Y312) polyclonal antibody
产品编号： PAB7764
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic phosphopeptide of AKT1/AKT2/AKT3.
- Immunogen:
- Synthetic phosphopeptide corresponding to residues surrounding Y315/Y316/Y312 of human AKT1/AKT2/AKT3.
- Host:
- Rabbit
- Theoretical MW (kDa):
- 60
- Reactivity:
- Human, Mouse, Rat
- Form:
- Liquid
- Purification:
- Immunoaffinity purification
- Concentration:
- 1 mg/mL
- Storage Buffer:
- In PBS (without Mg2+ and Ca2+), 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
- Storage Instruction:
- Store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- Antibody Reactive Against Synthetic Peptide.
- Recommend Usage:
- Immunohistochemistry (1:50-1:100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Entrez GeneID:
- 207
- Protein Accession#:
- P31749 P31751 Q9Y243
- Gene Name:
- AKT1
- Gene Alias:
- AKT,MGC99656,PKB,PKB-ALPHA,PRKBA,RAC,RAC-ALPHA
- Gene Description:
- v-akt murine thymoma viral oncogene homolog 1
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq
- Other Designations:
- RAC-alpha serine/threonine-protein kinase,murine thymoma viral (v-akt) oncogene homolog-1,protein kinase B,rac protein kinase alpha
- Entrez GeneID:
- 208
- Protein Accession#:
- P31749 P31751 Q9Y243
- Gene Name:
- AKT2
- Gene Alias:
- PKBB,PKBBETA,PRKBB,RAC-BETA
- Gene Description:
- v-akt murine thymoma viral oncogene homolog 2
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins. [provided by RefSeq
- Other Designations:
- Murine thymoma viral (v-akt) homolog-2,rac protein kinase beta
- Entrez GeneID:
- 10000
- Protein Accession#:
- P31749 P31751 Q9Y243
- Gene Name:
- AKT3
- Gene Alias:
- DKFZp434N0250,PKB-GAMMA,PKBG,PRKBG,RAC-PK-gamma,RAC-gamma,STK-2
- Gene Description:
- v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
- Omim ID:
- 611223
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. [provided by RefSeq
- Other Designations:
- OTTHUMP00000037911,OTTHUMP00000037912,RAC-gamma serine/threonine protein kinase,protein kinase B gamma,serine threonine protein kinase, Akt-3,v-akt murine thymoma viral oncogene homolog 3
