FIH, Factor inhibiting HIF1 (hypoxia-inducible factor), is an asparaginyl hydroxylase. FIH in conjunction with VHL
represses HIF-1 transcriptional activity by disrupting the
interaction of HIF-1 with the transcriptional co-activators
CBP/p300, and by recruiting histone deacetylases. FIH
activity is inhibited during hypoxia (1-3).
Recent studies show that low nuclear expression of FIH is
a strong independent prognostic factor for a poor overall
survival in clear cell renal cell carcinoma (4).